DNA Methylation Pathway Profile
Selected Genetic Variants Related to Metabolic Pathways
What is This Test?
This profile uses a cheek swab to assess selected genetic variants associated with metabolic pathways. Your genotype does not directly measure pathway activity, nutrient levels, detoxification capacity, or a symptom's cause. A variant alone is not a diagnosis or a reason to take supplements. Confirm the current panel offered through your patient chart and discuss its relevance with your clinician.
Confirm the exact panel, eligibility, preparation, and timing in your Fullscript order and current lab instructions. Kit instructions take priority over this general summary. Do not stop prescribed medicines without your clinician's guidance. Laboratory certification does not establish that every proposed clinical use is validated.
Biomarkers Tested
Folate & B12 Metabolism
- MTHFR (C677T, A1298C, MTHFR-3) — folate metabolism & DNA synthesis
- MTR (A2756G) — homocysteine to methionine conversion
- MTRR (A66G, H595Y, K350A, R415T, S257T) — B12 regeneration & nerve function
- SHMT (C1420T) — glycine/serine conversion & amino acid metabolism
Detoxification Pathways
- CBS (A360A, C699T, N212N) — sulfur metabolism & liver detoxification
- SUOX (S370S) — sulfite oxidation & toxin clearance
- NOS (D298E) — nitric oxide production & vascular health
Neurotransmitter & Hormone Balance
- COMT (COMT-61, H62H, V158M) — dopamine & stress hormone breakdown
- MAO A (R297R) — neurotransmitter metabolism & mood regulation
Vitamin D Function
- VDR Fok1 — Vitamin D receptor function & bone health
- VDR Taq1 — Vitamin D metabolism & immune regulation
What Should You Discuss Before Testing?
Genetic Testing Discussion
Ask whether the selected variants would provide useful information for your care.
Limits and Privacy
Discuss interpretation, consent, and genetic data handling before ordering.
Understanding Your Results
Your results report identifies your specific genetic variations and explains how they may affect your biochemistry, with actionable recommendations.
What You Can Review:
- 1Summary of all SNPs tested with your specific genotype
- 2Context for selected genetic variants
- 3Limitations of genotype-based interpretation
- 4Questions for your clinician or genetic counselor
- 5No direct measurement of nutrient levels or pathway efficiency
How to Test
At-home buccal swab (cheek cells) collection — simple and painless
- 1Receive your collection kit in the mail (arrives within 3-5 days)
- 2Use the buccal swab to gently collect cells from the inside of your cheek
- 3Collection takes less than 1 minute — completely painless and non-invasive
- 4Use the prepaid shipping label to send your sample to the certified lab
- 5Results are typically available 14-21 days after completing your test
Personal analysis included with testing
Alyssa's personal analysis is covered by the education resource fee shown when you purchase testing in Fullscript. Start with the quiz for individual testing guidance; checkout on this website remains paused.
Need Help Choosing?
Start the Gut First Gut Health Quiz. Alyssa reviews your answers before following up with guidance.
Take the Gut First Gut Health Quiz